Simulating the Dynamics of T Cell Subsets Throughout the Lifetime

摘要

It is widely accepted that the immune system undergoes age-related changescorrelating with increased disease in the elderly. T cell subsets have beenimplicated. The aim of this work is firstly to implement and validate asimulation of T regulatory cell (Treg) dynamics throughout the lifetime, basedon a model by Baltcheva. We show that our initial simulation produces aninversion between precursor and mature Treys at around 20 years of age, thoughthe output differs significantly from the original laboratory dataset.Secondly, this report discusses development of the model to incorporate newdata from a cross-sectional study of healthy blood donors addressing balancebetween Treys and Th17 cells with novel markers for Treg. The potential forsimulation to add insight into immune aging is discussed.